Given its health benefits to the human body, quercetin (QT) offers promising applications in the healthcare food and pharmaceutical industries. However, the instability, low water solubility and low bioavailability of QT remain to be solved. In this paper, cellulose nanofiber (CNF) was used as an effective nanoscale carrier to alleviate these problems. By adjusting the solvent composition ratio and processing method, QT was optimally immobilized on CNF surfaces and was eventually encapsulated in the CNF matrices, forming a CNF/QT nanoformulation. A high loading capacity of 78.91% and encapsulation efficiency of 88.77% were achieved simultaneously. The nanoformulation exhibited better dietary performance and antioxidant activity than raw QT. Moreover, sustained release of QT was demonstrated in vitro. These results reveal that CNF is an ideal natural nanoscale dietary carrier and offers high encapsulation efficiency for healthcare supplementation. This work also provides a promising nanoformulation candidate for managing sustained antioxidant requirements.

槲皮素（QT）鉴于其对人体的健康益处，在保健食品和制药行业中提供了有希望的应用。然而，QT的不稳定性，低水溶性和低生物利用度仍有待解决。在本文中，纤维素纳米纤维（CNF）被用作缓解这些问题的有效纳米级载体。通过调整溶剂组成比和加工方法，将QT最佳地固定在CNF表面，并最终封装在CNF基质中，形成CNF / QT纳米制剂。同时实现了78.91％的高负载能力和88.77％的封装效率。纳米制剂显示出比未加工的QT更好的饮食性能和抗氧化活性。此外，在体外证明了QT的持续释放。这些结果表明，CNF是一种理想的天然纳米级膳食载体，并为医疗保健补充剂提供了高封装效率。这项工作还为管理持续的抗氧化剂需求提供了有希望的纳米制剂候选物。