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Characterization of circulating tumor cells as a reflection of the tumor heterogeneity: myth or reality?
Drug Discovery Today ( IF 7.4 ) Pub Date : 2018-11-26 , DOI: 10.1016/j.drudis.2018.11.017
Hannah K. Brown , Marta Tellez-Gabriel , Pierre-François Cartron , François M. Vallette , Marie-Francoise Heymann , Dominique Heymann

The current main goal of diagnostic medicine is to detect crucial events in ‘infinitely’ small samples. The key question now is how to determine whether the rare cell events isolated and characterized from these samples reliably reflect the disease and heterogeneity of the tumor. In this review, we provide a short overview of the most recent methods developed for the isolation and characterization of rare cell events in clinical practice, with a specific focus on circulating tumor cells. We discuss the biological value to studying these cells at the single cell level and how these rare cell events can reflect tumor heterogeneity. The potential biomedical applications are also critically discussed in light of precision medicine.



中文翻译:

循环肿瘤细胞的表征反映了肿瘤的异质性:神话还是现实?

诊断医学的当前主要目标是检测“无限”少量样品中的关键事件。现在的关键问题是如何确定从这些样品中分离并表征的稀有细胞事件是否能可靠地反映出疾病和肿瘤的异质性。在这篇综述中,我们简要概述了为临床实践中稀有细胞事件的分离和表征开发的最新方法,特别关注循环肿瘤细胞。我们讨论了在单细胞水平研究这些细胞的生物学价值,以及这些稀有细胞事件如何反映肿瘤异质性。鉴于精密医学,还对潜在的生物医学应用进行了严格的讨论。

更新日期:2018-11-26
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