We report the development of a continuous flow approach for the preparation of two bio-derived monomer libraries. A small range of terpenes (ocimene, myrcene, α-terpinene, α-phellandrene, isoprene, and farnesene) have been used as the base set for the library, with the first library derived from a Diels–Alder reaction with the platform chemical maleic anhydride. The second library requires the derivatization of the first through a hydrogenation reaction. The potential for scale-up of both libraries has been demonstrated, with the Diels–Alder process delivering 10.5 grams of the product in 3 hours and the hydrogenation process delivering 10 grams of the material in 16 hours.

中文翻译：

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连续流处理可作为生成萜烯衍生单体库的工具†

我们报告了用于制备两个生物来源的单体库的连续流方法的发展。小范围的萜烯（罗勒烯，月桂烯，α-萜烯，α-水芹烯，异戊二烯和法呢烯）已被用作该文库的基础，第一个文库衍生自Diels-Alder反应与平台化学马来酸的反应酐。第二个库需要通过氢化反应将第一个库衍生化。事实证明，这两个库都有扩大规模的潜力，Diels–Alder工艺可在3小时内输送10.5克产品，而氢化工艺可在16小时内输送10克物料。