To overcome the disadvantage of current antibiotic bone cements with low drug elution efficiency, the hollow nanostructured titanium-dioxide (TiO₂) nanotubes (TNTs) were formulated with antibiotic loaded bone cement to create nano diffusion networks, enabling enhanced release of antibiotic. By incorporation of TNTs into Poly(methyl methacrylate) (PMMA) based bone cement, more than 50% of loaded antibiotic (such as gentamicin or vancomycin) could be released in two months. As comparison, only about 5% of total drug release was achieved in the absence of TNTs. The mechanical properties of PMMA-based bone cements were well preserved after incorporation of TNTs. Furthermore, the compression strength and bending modules of TNTs formulated antibiotic bone cements could be maintained after the drug release for 70 days or aging in PBS buffer for 3 months. The insoluble TNTs in bone cement is believed to support the mechanical properties after wet aging.

为了克服当前抗生素骨水泥的药物洗脱效率低的缺点，空心纳米结构二氧化钛（TiO ₂用载有抗生素的骨水泥配制纳米管（TNT），以创建纳米扩散网络，从而增强抗生素的释放。通过将TNT掺入基于聚甲基丙烯酸甲酯（PMMA）的骨水泥中，可以在两个月内释放超过50％的负载抗生素（例如庆大霉素或万古霉素）。相比之下，在不存在TNT的情况下，仅实现了约5％的总药物释放。掺入TNT后，可以很好地保留PMMA基骨水泥的机械​​性能。此外，在药物释放70天或在PBS缓冲液中老化3个月后，可以维持TNTs配制的抗生素骨水泥的抗压强度和弯曲模量。据信，骨水泥中的不溶性TNT在湿老化后可支持机械性能。