Abstract Chronic wound management is challenging and is further intensified due to its increasing prevalence attributed to escalation of ailments like diabetes. Presence of exudates further sustains the chronicity and is a significant burden for the healthcare sector. In this work, a wound dressing material has been formulated in the form of a lyophilized hydrogel comprising of alginate, gelatin and polyvinyl alcohol, with an aim to absorb exudates, maintain a moist environment and enhance interaction with the tissues. Triiodothyronine (active form of thyroid hormone) having vital role in repair and regeneration of tissues is incorporated in the scaffold to bolster the healing process. The fabricated scaffold is physicochemically characterized and the release of hormone has been analysed. The scaffold promotes neovasculature development, skin cell proliferation and migration with cell-biomaterial interaction and lamellipodia formation (observed by phalloidin staining). Animal experiment studies (full-thickness excision wounds created in Wistar rat model) substantiated the explicit potential of the scaffold to encourage faster wound healing. Histological studies further corroborated enhanced healing progression with blood vessel development and collagen deposition. Hence the fabricated scaffold possesses immense potential to be exploited as a chronic wound therapeutic.

中文翻译：

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三碘甲腺原氨酸浸渍海藻酸盐/明胶/聚乙烯醇复合支架设计用于渗出液密集伤口治疗

摘要 慢性伤口管理具有挑战性，并且由于糖尿病等疾病的升级导致其患病率增加而进一步加剧。渗出液的存在进一步维持了慢性病，并且是医疗保健部门的重大负担。在这项工作中，伤口敷料材料以冻干水凝胶的形式配制，由海藻酸盐、明胶和聚乙烯醇组成，目的是吸收渗出液，保持潮湿环境并增强与组织的相互作用。三碘甲腺原氨酸（甲状腺激素的活性形式）在组织修复和再生中具有重要作用，被纳入支架以促进愈合过程。制造的支架进行了物理化学表征，并分析了激素的释放。支架促进新血管发育，皮肤细胞增殖和迁移与细胞-生物材料相互作用和片状伪足形成（通过鬼笔环肽染色观察）。动物实验研究（在 Wistar 大鼠模型中产生的全层切除伤口）证实了支架在促进伤口更快愈合方面的显着潜力。组织学研究进一步证实了血管发育和胶原蛋白沉积促进愈合进程。因此，制造的支架具有作为慢性伤口治疗剂开发的巨大潜力。组织学研究进一步证实了血管发育和胶原蛋白沉积促进愈合进程。因此，制造的支架具有作为慢性伤口治疗剂开发的巨大潜力。组织学研究进一步证实了血管发育和胶原蛋白沉积促进愈合进程。因此，制造的支架具有作为慢性伤口治疗剂开发的巨大潜力。