A new series of 1,3,4-oxadiazole/chalcone hybrids was designed, synthesized, identified with different spectroscopic techniques and biologically evaluated as inhibitors of EGFR, Src, and IL-6. The synthesized compounds showed promising anticancer activity, particularly against leukemia, with 8v being the most potent. The synthesized compounds exhibited strong to moderate cytotoxic activities against K-562, KG-1a, and Jurkat leukemia cell lines in MTT assays. Compound 8v showed the strongest cytotoxic activity with IC50 of 1.95 µM, 2.36 µM and 3.45 µM against K-562, Jurkat and KG-1a leukemia cell lines, respectively. Moreover; the synthesized compounds inhibited EGFR, Src, and IL-6. Compound 8v was most effective at inhibiting EGFR (IC50 = 0.24 μM), Src (IC50 = 0.96 μM), and IL-6 (% of control = 20%). Additionally, most of the compounds decreased STAT3 activation.

中文翻译：

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1,3,4-恶二唑/查耳酮杂种：设计，合成和抑制白血病细胞生长以及EGFR，Src，IL-6和STAT3活性。

设计，合成，使用不同的光谱技术鉴定了一系列新的1,3,4-恶二唑/查耳酮杂化物，并对其进行了生物学评估，认为它们是EGFR，Src和IL-6的抑制剂。合成的化合物显示出有希望的抗癌活性，尤其是针对白血病，最有效的是8v。在MTT分析中，合成的化合物对K-562，KG-1a和Jurkat白血病细胞系表现出强至中等的细胞毒活性。化合物8v对K-562，Jurkat和KG-1a白血病细胞株表现出最强的细胞毒活性，IC50分别为1.95 µM，2.36 µM和3.45 µM。而且; 合成的化合物可抑制EGFR，Src和IL-6。化合物8v最有效地抑制EGFR（IC50 = 0.24μM），Src（IC50 = 0.96μM）和IL-6（对照％= 20％）。此外，