Abstract Dopamine (DA), a typical catechol-containing monomer, which has been well reported for its excellent applications in biomedical research, was used to modify alginate (ALG) hydrogel for better gel formation and performance which are needed for drug delivery. By our design, Polydopamine (PDA) particles embedded ALG hydrogel (ALG-PDA), two types of DA and ALG co-polymerized hydrogels (ALG-DA-AS, ALG-DA-SP) which were initiated by ammonia aqueous solution (AS) and sodium periodate (SP), respectively, were successfully prepared. The status of incorporated DA/PDA and their interactions with hydrogel skeleton were investigated by chemical structure, morphology and rheology characterizations. Interestingly, a self-gelation process was discovered during ALG-DA-SP preparation, which is supposed to be the crosslinking formation via the aromatic interaction and hydrogen bonding between catechol or o-benzoquinone modified ALG molecules. Such self-crosslinked structure was proved helpful to improve the structural stability of gel even in saline environment. The effects of DA, SP concentration on the self-gelation process were discussed. The good biocompatibility of PDA material was also confirmed by a cytotoxicity test. In loading and release experiments, all the modified hydrogels were proved to have better adsorption ability to gatifloxacin (GFLX) and more steady in vitro release behavior than pristine ALG hydrogel.

中文翻译：

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多巴胺/聚多巴胺改性海藻酸盐水凝胶的制备方法及其特殊的药物递送性能

摘要 多巴胺 (DA) 是一种典型的含儿茶酚单体，因其在生物医学研究中的出色应用而被广泛报道，可用于修饰海藻酸盐 (ALG) 水凝胶，以获得更好的凝胶形成和药物递送所需的性能。根据我们的设计，聚多巴胺 (PDA) 颗粒嵌入了 ALG 水凝胶 (ALG-PDA)，两种类型的 DA 和 ALG 共聚水凝胶 (ALG-DA-AS、ALG-DA-SP) 由氨水溶液 (AS) 引发) 和高碘酸钠 (SP) 分别制备成功。通过化学结构、形态和流变学表征研究了掺入 DA/PDA 的状态及其与水凝胶骨架的相互作用。有趣的是，在 ALG-DA-SP 制备过程中发现了自凝胶过程，这应该是通过邻苯二酚或邻苯醌修饰的 ALG 分子之间的芳香相互作用和氢键形成的交联。这种自交联结构被证明有助于提高凝胶的结构稳定性，即使在盐水环境中也是如此。讨论了DA、SP浓度对自凝胶过程的影响。PDA 材料的良好生物相容性也通过细胞毒性试验得到证实。在加载和释放实验中，所有修饰的水凝胶都被证明对加替沙星（GFLX）具有更好的吸附能力和比原始 ALG 水凝胶更稳定的体外释放行为。讨论了DA、SP浓度对自凝胶过程的影响。PDA 材料的良好生物相容性也通过细胞毒性试验得到证实。在加载和释放实验中，所有修饰的水凝胶都被证明对加替沙星（GFLX）具有更好的吸附能力和比原始 ALG 水凝胶更稳定的体外释放行为。讨论了DA、SP浓度对自凝胶过程的影响。PDA 材料的良好生物相容性也通过细胞毒性试验得到证实。在加载和释放实验中，所有修饰的水凝胶都被证明对加替沙星（GFLX）具有更好的吸附能力和比原始 ALG 水凝胶更稳定的体外释放行为。