Carboxymethyl-β-cyclodextrin (CM-β-CD) was introduced to obtain surface-modified nanohydroxyapatite (CM-β-CD-HA). The results of Fourier transform infrared, X-ray diffraction (XRD), dispersion testing, X-ray photoelectron spectroscopy, and thermal gravimetric analysis showed that CM-β-CD was surface-grafted onto nanohydroxyapatite (n-HA) by the reaction of a carboxyl group of CM-β-CD with Ca²⁺ ions during the formation of n-HA. The best appropriate reaction condition was obtained, which accomplished CM-β-CD-HA with the greatest grafting amount and best dispersion. Then, CM-β-CD-HA was introduced to poly(lactic-co-glycolide) (PLGA) with different amounts of 5, 10, and 15 wt % by a solution mixing method, and the properties of CM-β-CD-HA/PLGA composites were also investigated by electromechanical universal testing, XRD, scanning electron microscopy, differential scanning calorimetry, and polarized optical microscopy. The results indicated that CM-β-CD-HA with 10 wt % had the best mechanical reinforcing effectiveness for PLGA, whose tensile strength of the CM-β-CD-HA/PLGA composite was 14.84% higher than that of pure PLGA because of its best dispersion and promotion crystallization, suggesting that CM-β-CD-HA obtained by the new surface-modification strategy has great potential to be used as a reinforcing filler for PLGA as a bone material in the future.

中文翻译：

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高度分散的纳米羟基磷灰石的新的表面改性战略用作增强填料的聚（乳酸-准备联合-glycolide）

引入羧甲基-β-环糊精（CM-β-CD）以获得表面改性的纳米羟基磷灰石（CM-β-CD-HA）。傅里叶变换红外，X射线衍射（XRD），色散测试，X射线光电子能谱和热重分析的结果表明，CM-β-CD是通过以下反应而表面接枝到纳米羟基磷灰石（n-HA）上的n-HA形成过程中带有Ca ²⁺离子的CM-β-CD的羧基。获得了最佳的适宜反应条件，以最大的接枝量和最佳的分散度完成了CM-β-CD-HA。然后，CM-β-CD-HA引入到聚（乳酸-共溶液混合法分别添加了5、10和15 wt％的聚乙交酯（PLGA），并通过机电通用测试，X射线衍射，扫描电子对CM-β-CD-HA/ PLGA复合材料的性能进行了研究。显微镜，差示扫描量热法和偏振光学显微镜。结果表明，CM-β-CD-HA/ PLGA复合材料的质量分数为10 wt％时，CM-β-CD-HA对PLGA的机械强度最佳，CM-β-CD-HA/ PLGA复合材料的拉伸强度比纯PLGA高14.84％。其最佳的分散和促进结晶作用，表明通过新的表面改性策略获得的CM-β-CD-HA在将来用作PLGA骨材料的增强填料方面具有巨大的潜力。