Cyclization of the furfural and secondary amines to generate trans-4,5-diaminocyclopentanes is a significant reaction in pharmaceutical industry. Herein, MIL-series MOF are synthesized to catalyze the cyclization with a higher activity over 99.9% and selectivity above 98.2% than homogeneous metal chloride (82.4%, 84.3%) because of its large surface area and suitable shape selectivity. The adjustable pore size of MOF shows a universal applicability for different molecular size secondary amines (pyrrolidine, piperidine, indoline and tetrahydroquinoline). Moreover, the catalyst is stable after 5 runs. This study provides a promising route for pharmaceutical chemisty involving macromolecular reaction by MOF-based heterogeneous catalysts.

糠醛和仲胺的环化生成反式4,5-二氨基环戊烷是制药工业中的重要反应。本文中，MIL系列MOF的合成具有催化作用，其环比大，且具有适当的形状选择性，因此比均相金属氯化物（82.4％，84.3％）具有更高的活性（超过99.9％）和选择性（高于98.2％）。MOF的可调孔径显示了对不同分子大小的仲胺（吡咯烷，哌啶，二氢吲哚和四氢喹啉）的普遍适用性。此外，催化剂在5次运行后是稳定的。这项研究为涉及基于MOF的非均相催化剂的大分子反应的药物化学提供了一条有希望的途径。