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Harnessing Cyanine Reactivity for Optical Imaging and Drug Delivery
Accounts of Chemical Research ( IF 18.3 ) Pub Date : 2018-11-12 00:00:00 , DOI: 10.1021/acs.accounts.8b00384
Alexander P. Gorka 1 , Roger R. Nani 1 , Martin J. Schnermann 1
Affiliation  

Optical approaches that visualize and manipulate biological processes have transformed modern biomedical research. An enduring challenge is to translate these powerful methods into increasingly complex physiological settings. Longer wavelengths, typically in the near-infrared (NIR) range (∼650–900 nm), can enable advances in both fundamental and clinical settings; however, suitable probe molecules are needed. The pentamethine and heptamethine cyanines, led by prototypes Cy5 and Cy7, are among the most useful compounds for fluorescence-based applications, finding broad use in a range of contexts. The defining chemical feature of these molecules, and the key chromophoric element, is an odd-numbered polymethine that links two nitrogen atoms. Not only a light-harvesting functional group, the cyanine chromophore is subject to thermal and photochemical reactions that dramatically alter many properties of these molecules.

中文翻译:

利用花菁反应性进行光学成像和药物输送

可视化和操纵生物过程的光学方法已经改变了现代生物医学研究。一项持久的挑战是将这些强大的方法转化为越来越复杂的生理环境。更长的波长(通常在近红外(NIR)范围内(约650-900 nm))可以在基础和临床环境中取得进步。但是,需要合适的探针分子。由原型Cy5和Cy7牵头的五甲胺和七甲胺花青是基于荧光的应用中最有用的化合物,在各种情况下都有广泛的用途。这些分子的主要化学特征以及主要的发色元素是连接两个氮原子的奇数次聚甲硫氨酸。不仅是光收集功能组,
更新日期:2018-11-12
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