Click‐crosslinking has been widely used for the fabrication of nanocarriers in recent years. Crosslinking can enhance the stability of nanocarriers that have served as an emerging platform for drug delivery to achieve cancer diagnosis and therapy. In crosslinking methods, click reactions have attracted increasing attention owing to their high reaction specificity and physiologically stable products. These reports on click‐crosslinked nanocarriers are divided into four sections (nanogels, nanoparticles, micelles, and capsules) according to the types of nanocarriers. Click‐crosslinked nanocarriers enhance the solubility of hydrophobic drugs and improve the efficacy of drug delivery owing to their good stability. Stimuli‐responsive and targeted strategies can be introduced into click‐crosslinked nanocarriers to enhance drug accumulation in tumors.

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点击交联纳米载体在药物输送领域的最新进展

近年来，点击交联已被广泛用于制造纳米载体。交联可增强纳米载体的稳定性，该纳米载体已成为药物递送以实现癌症诊断和治疗的新兴平台。在交联方法中，点击反应由于其高的反应特异性和生理上稳定的产物而引起了越来越多的关注。这些点击交联纳米载体的报告根据纳米载体的类型分为四个部分（纳米凝胶，纳米颗粒，胶束和胶囊）。单击交联的纳米载体由于其良好的稳定性而提高了疏水性药物的溶解度并提高了药物递送的效率。可以将刺激响应和靶向策略引入单击交联的纳米载体中，以增强肿瘤中的药物蓄积。