Abstract Cold is a leading cause of school and work absenteeism. Most cold over-the-counter medicines (OTC) contain paracetamol (PA), guaifenesin (GU) and other active ingredients. Ascorbic acid (AS) in pharmaceutical preparations is designed for preventing and treating respiratory viral infections. Thus, we report a robust voltammetric method for simultaneous determination of AS, PA and GU in their effervescent dosage form. The advantages of nanotechnology and chemometrics were combined to enhance the performance of electroanalysis. Fractional factorial design (FrFD) and dual response surface method (DRSM) were sequentially conducted. The method was validated in agreement with ICH guidelines; it showed accuracy over the concentration range of 11.3–108.9, 14.6–140.3, 4.6–43.9 μg ml−1 for AS, PA and GU, respectively. Based on findings, a robust and not time-consuming procedure was applied.

中文翻译：

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使用连续实验策略同时测定抗坏血酸、扑热息痛和愈创甘油醚的伏安法

摘要 寒冷是导致学校和工作旷工的主要原因。大多数感冒非处方药 (OTC) 都含有扑热息痛 (PA)、愈创甘油醚 (GU) 和其他活性成分。药物制剂中的抗坏血酸 (AS) 旨在预防和治疗呼吸道病毒感染。因此，我们报告了一种强大的伏安法，可同时测定泡腾剂型中的 AS、PA 和 GU。结合纳米技术和化学计量学的优势，提高了电分析的性能。部分因子设计 (FrFD) 和双响应面法 (DRSM) 依次进行。该方法经验证符合 ICH 指南；对于 AS、PA 和 GU，它分别在 11.3–108.9、14.6–140.3、4.6–43.9 μg ml-1 的浓度范围内显示出准确度。根据调查结果，