Abstract Dextran-based formulations represent promising candidates for the fabrication of biocompatible scaffolds in tissue engineering or as vehicles for drug delivery. Previous investigations showed that, on its own, dextran is able to promote wound healing in vivo in rat models. Its inherent solubility in water, however, must be overcome by inserting inter-molecular junctions via the use of cross-linkers. While conventional cross-linking methods tend to utilize toxic compounds, such as glutaraldehyde, we demonstrate that simple mixtures of dextran and boric acid, in aqueous solutions, can be electrospun to obtain membranes with controlled degradation times. Boric acid covalently links to the hydroxyls moieties present in the dextran chains yielding boronate ester bridges between dextran chains. Variation in the cross-linking density enhanced the average drug release time up to 500% compared to pristine dextran electrospun scaffolds.

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通过硼酸盐化学交联葡聚糖电纺纳米纤维：伤口贴片的概念证明

摘要 基于葡聚糖的制剂代表了在组织工程中制造生物相容性支架或作为药物递送载体的有希望的候选者。先前的研究表明，在大鼠模型中，葡聚糖本身能够促进体内伤口愈合。然而，它在水中的固有溶解度必须通过使用交联剂插入分子间连接来克服。虽然传统的交联方法倾向于使用有毒化合物，如戊二醛，但我们证明了葡聚糖和硼酸在水溶液中的简单混合物，可以通过电纺获得具有受控降解时间的膜。硼酸与葡聚糖链中存在的羟基部分共价连接，在葡聚糖链之间产生硼酸酯桥。