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Photoresponsive, Water‐Soluble Supramolecular Dendronized Polymer with Specific Lysosome‐Targetable Bioimaging Application in Living Cells
Macromolecular Rapid Communications ( IF 4.6 ) Pub Date : 2018-11-08 , DOI: 10.1002/marc.201800714
Hang Li 1 , Jie Wu 2 , Jia‐Fu Yin 1 , Huan Wang 1 , Yongquan Wu 2 , Gui‐Chao Kuang 1, 3
Affiliation  

A novel photoresponsive, water‐soluble supramolecular dendronized polymer (SDP) is prepared through a γ ‐cyclodextrin (γ ‐CD)‐coumarin host–guest interaction. The supramolecular formation, photoresponsive process, and fluorescence properties are investigated by nuclear magnetic resonance (NMR) techniques and spectrometric measurements. Upon different‐wavelength light irradiation, this supramolecular polymer undergoes noncovalent polymer and covalent polymer conversion due to coumarin cycloaddition and cleavage reactions. In addition, SDP for bioimaging in Michigan Cancer Foundation‐7 (MCF‐7) cells is performed and results show that the obtained SDP has good biocompatibility and is lysosome‐targetable. This research enriches the field of supramolecular dendrimers and the photo‐stimulation response material may have application prospects in organelle‐targeting applications.

中文翻译:

具有光响应性的水溶性超分子树枝状聚合物,在活细胞中具有特定的溶酶体靶向生物成像应用

通过γ-环糊精(γ-CD)-香豆素主-客体相互作用,制备了一种新型的光响应性水溶性超分子树枝状聚合物(SDP)。超分子的形成,光响应过程和荧光性质通过核磁共振(NMR)技术和光谱测量进行了研究。在不同波长的光照射下,由于香豆素环加成和裂解反应,该超分子聚合物经历了非共价聚合物和共价聚合物的转化。此外,在密歇根州癌症基金会-7(MCF-7)细胞中进行了用于生物成像的SDP,结果表明所获得的SDP具有良好的生物相容性并且可溶酶体靶向。
更新日期:2018-11-08
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