Staphylococcus aureus is a bacterial pathogen that can cause significant disease burden and mortality by counteracting host defenses through producing virulence factors to survive the immune responses evoked by infection. This emerging drug-resistant pathogen has led to a decline in the efficacy of traditional antimicrobial therapy. To combat these threats, precision antimicrobial therapeutics have been created to target key virulence determinants of specific pathogens. Here we review the benefits of, progresses in, and roadblocks to the development of precision antimicrobial therapeutics using combinatorial chemistry.

中文翻译：

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与主要操纵者作斗争：金黄色葡萄球菌免疫调节分子作为组合药物发现的靶标

金黄色葡萄球菌是一种细菌病原体，可通过产生毒力因子抵抗宿主防御，从而抵抗感染引起的免疫反应，从而导致重大疾病负担和死亡率。这种新兴的耐药性病原体导致传统抗菌疗法的功效下降。为了应对这些威胁，已经创建了精确的抗微生物治疗剂来靶向特定病原体的关键毒力决定因素。在这里，我们回顾了使用组合化学开发精密抗菌疗法的好处，进展和障碍。