Autophagy is an intracellular degradation system conserved among eukaryotes that mediates the degradation of various biomolecules and organelles. During autophagy, a double membrane-bound organelle termed an autophagosome is synthesized de novo and delivers targets from the cytoplasm to the lysosomes for degradation. Autophagosome formation involves complex and dynamic membrane rearrangements, which are regulated by dozens of autophagy-related (Atg) proteins. In this review, we summarize our current knowledge of membrane-binding domains and motifs in Atg proteins and discuss their roles in autophagy.

中文翻译：

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自噬中的膜结合域

自噬是真核生物中保守的细胞内降解系统，介导各种生物分子和细胞器的降解。在自噬过程中，称为“自噬体”的双膜结合细胞器是从头合成的，并将靶标从细胞质传递到溶酶体进行降解。自噬体的形成涉及复杂且动态的膜重排，其受数十种自噬相关（Atg）蛋白调控。在这篇综述中，我们总结了我们目前对Atg蛋白中的膜结合域和基序的了解，并讨论了它们在自噬中的作用。