Background

Limited information exists on the influence of demographics, tumor characteristics, and treatment on survival in cutaneous pleomorphic sarcoma (CPS).

Objective

To describe incidence rates and prognostic factors affecting survival in CPS.

Methods

National Cancer Institute's Surveillance, Epidemiology, and End Results data (1972-2013) was analyzed for 2423 patients with CPS diagnoses.

Results

The age-adjusted incidence rate was 0.152 cases/100,000 person-years and was 4.5-fold higher in male than female patients. Male sex, white race, and increasing age >40 years were significantly associated with decreased overall survival. Head and neck tumors, tumors >15 mm, and tumors with grade III or IV histology were associated with significantly decreased survival. Surgical excision had a survival benefit compared with no treatment. Radiation therapy did not provide a survival benefit. Patients with localized disease had the greatest survival followed by regional and distant disease.

Limitations

Surveillance, Epidemiology, and End Results data might not be reflective of all CPS patients. Recurrences, restaging, or other nonmortality events over time were not tracked.

Conclusion

Tumor size, grade, sex, age at diagnosis, and race appear to influence survival as prognostic factors in CPS. Surgical tumor extirpation provides a survival benefit over no treatment whereas primary or adjuvant radiation does not provide a survival benefit.

中文翻译：

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皮肤多形性肉瘤的预后因素，治疗和生存率。

背景

关于人口统计学，肿瘤特征和治疗对皮肤多形性肉瘤（CPS）存活率的影响的信息有限。

客观的

描述影响CPS生存的发生率和预后因素。

方法

美国国家癌症研究所（National Cancer Institute）的监测，流行病学和最终结果（1972-2013）数据分析了2423例CPS诊断的患者。

结果

年龄调整后的发病率为0.152例/ 100,000人年，男性比女性高4.5倍。男性，白人，年龄增加到40岁以上与总体生存率下降显着相关。头颈部肿瘤，> 15 mm的肿瘤以及组织学分级为III或IV的肿瘤与生存率显着降低有关。与不治疗相比，外科手术切除术具有生存优势。放射疗法未提供生存益处。局部疾病患者的生存率最高，其次是区域性疾病和远距离疾病。

局限性

监测，流行病学和最终结果数据可能无法反映所有CPS患者。没有跟踪随着时间的推移发生的复发，重新分期或其他非死亡事件。

结论

肿瘤大小，等级，性别，诊断年龄和种族似乎会影响生存，这是CPS的预后因素。手术切除肿瘤比不进行治疗可提供生存获益，而原发或辅助放疗则不能带来生存获益。