当前位置: X-MOL 学术Neuropsychopharmacology › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Intrinsic functional connectivity correlates of person-level risk for bipolar disorder in offspring of affected parents.
Neuropsychopharmacology ( IF 7.6 ) Pub Date : 2018-11-08 , DOI: 10.1038/s41386-018-0264-9
Danella M Hafeman 1 , Henry W Chase 1 , Kelly Monk 1 , Lisa Bonar 1 , Mary Beth Hickey 1 , Alicia McCaffrey 1 , Simona Graur 1 , Anna Manelis 1 , Cecile D Ladouceur 1 , John Merranko 1 , David A Axelson 2 , Benjamin I Goldstein 3 , Tina R Goldstein 1 , Boris Birmaher 1 , Mary L Phillips 1
Affiliation  

Offspring of parents with bipolar disorder (OBP) are at increased risk to develop bipolar disorder (BD). Alterations in resting-state functional connectivity (rsFC) have been identified in OBP; however, replication has been limited and correlation with person-level risk is unknown. A recent study found reduced rsFC between left inferior frontal gyrus (IFG) and clusters in the left insula (LINS), lentiform nucleus (LENT), and midcingulate cortex (MCING) in OBP (Roberts et al. 2017); here, we aim to extend these findings to at-risk youth. We scanned a subset of the Pittsburgh Bipolar Offspring Study, a longitudinal study of OBP and community controls. Twenty-four OBP, 20 offspring of control parents with non-bipolar psychopathology (OCP), and 27 healthy controls (HC) had acceptable rsFC data. After preprocessing steps, we assessed group differences in seed-based rsFC between the IFG and target clusters (LINS, LENT, MCING) using multivariate regression. Next, we tested whether rsFC correlated with person-level risk score and with other dimensional measures. We did not find group differences in rsFC between IFG and target regions. Within OBP, risk score negatively correlated with IFG-LINS rsFC (p = 0.002). Across groups, mood lability correlated negatively with rsFC between IFG and target regions (p = 0.0002), due to negative correlation with IFG-LINS (p = 0.0003) and IFG-MCING (p = 0.001) rsFC. While group-level differences were not replicated, IFG-LINS rsFC was negatively correlated with a person-level risk score in OBP and with mood lability (a predictor of BD) across the sample. Thus, IFG-LINS rsFC might constitute a risk marker, within OBP, for the development of BD.

中文翻译:

本质上的功能连通性与受影响父母的后代患双相情感障碍的人水平风险相关。

患有双相情感障碍(OBP)的父母的后代患双相情感障碍(BD)的风险增加。OBP中已经确定了静态功能连接(rsFC)的变化;但是,复制受到限制,并且与个人风险的相关性未知。最近的一项研究发现,OBP的左下额叶回(IFG)与左岛岛(LINS),扁形核(LENT)和中齿皮层(MCING)之间的rsFC降低(Roberts等人2017); 在这里,我们旨在将这些发现扩展到处于危险中的年轻人。我们扫描了匹兹堡双极后代研究的一部分,这是对OBP和社区控制的纵向研究。24例OBP,20例具有非双相精神病理学(OCP)的对照父母的后代和27例健康对照(HC)的rsFC数据均可接受。经过预处理步骤后,我们使用多元回归评估了IFG和目标群(LINS,LENT,MCING)之间基于种子的rsFC的组差异。接下来,我们测试了rsFC是否与个人级别的风险评分以及其他维度度量相关。我们没有发现IFG和目标地区之间的rsFC组差异。在OBP内,风险评分与IFG-LINS rsFC呈负相关(p = 0.002)。在各组中,由于与IFG-LINS(p = 0.0003)和IFG-MCING(p = 0.001)rsFC呈负相关,因此情绪不稳定与IFG和目标区域之间的rsFC呈负相关(p = 0.0002)。虽然没有复制组间的差异,但IFG-LINS rsFC与个人水平的OBP风险评分以及整个样本中的情绪不稳定性(BD的预测因子)呈负相关。因此,IFG-LINS rsFC可能在OBP中构成风险标记,
更新日期:2018-11-08
down
wechat
bug