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Slice-illuminated optical projection tomography
Optics Letters ( IF 3.6 ) Pub Date : 2018-11-06 , DOI: 10.1364/ol.43.005555
Samuel P. X. Davis , Laura Wisniewski , Sunil Kumar , Teresa Correia , Simon R. Arridge , Paul Frankel , James McGinty , Paul M. W. French

To improve the imaging performance of optical projection tomography (OPT) in live samples, we have explored a parallelized implementation of semi-confocal line illumination and detection to discriminate against scattered photons. Slice-illuminated OPT (sl-OPT) improves reconstruction quality in scattering samples by reducing interpixel crosstalk at the cost of increased acquisition time. For in vivo imaging, this can be ameliorated through the use of compressed sensing on angularly undersampled OPT data sets. Here, we demonstrate sl-OPT applied to 3D imaging of bead phantoms and live adult zebrafish.

中文翻译:

切片照明光学投影断层扫描

为了提高活体样本中光学投影断层扫描(OPT)的成像性能,我们探索了半共焦线照明和检测的并行实现,以区分散射光子。切片照明 OPT (sl-OPT) 通过减少像素间串扰来提高散射样本的重建质量,但代价是增加采集时间。对于体内成像,可以通过在角度欠采样 OPT 数据集上使用压缩感知来改善这一问题。在这里,我们演示了 sl-OPT 应用于珠体模型和活体成年斑马鱼的 3D 成像。
更新日期:2018-11-16
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