Diselenide‐bond‐linked poly(N‐isopropylacrylamide)‐paclitaxel chemical conjugates are synthesized as a drug release carrier. The conjugates can self‐assemble into “core–shell” nanoscaled micelles in aqueous solution and show thermal and redox dual‐responsiveness. The conjugates can afford a high encapsulation efficiency of up to 72.3%, and deliver hydrophobic anticancer drug paclitaxel in a temperature and oxidization or reduction stress‐mode. The in vitro 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) and in vivo anticancer assays are performed to assess the cytotoxicity and anticancer activity of the conjugates, suggesting that the developed conjugates can be used to treat carcinoma as a novel and highly efficient drug delivery system.

中文翻译：

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化学共轭自组装的双刺激响应性紫杉醇递送纳米系统在癌症治疗中的作用

合成二硒键结合的聚（N-异丙基丙烯酰胺）-紫杉醇化学共轭物作为药物释放载体。缀合物可以在水溶液中自组装成“核-壳”纳米级胶束，并显示出热和氧化还原双重反应性。结合物可提供高达72.3％的高封装效率，并在温度和氧化或还原应力模式下提供疏水性抗癌药物紫杉醇。进行了体外3-（4,5-二甲基-2-噻唑基）-2,5-二苯基-2-H-四唑溴化物（MTT）和体内抗癌试验，以评估缀合物的细胞毒性和抗癌活性，提示开发的结合物可用于治疗癌症，将其作为一种新型且高效的药物递送系统。