Langmuir monolayers provide a fast and elegant route to analyze the degradation behavior of biodegradable polymer materials. In contrast to bulk materials, diffusive transport of reactants and reaction products in the (partially degraded) material can be neglected at the air–water interface, allowing for the study of molecular degradation kinetics in experiments taking less than a day and in some cases just a few minutes, in contrast to experiments with bulk materials that can take years. Several aspects of the biodegradation behavior of polymer materials, such as the interaction with biomolecules and degradation products, are directly observable. Expanding the technique with surface‐sensitive instrumental techniques enables evaluating the evolution of the morphology, chemical composition, and the mechanical properties of the degrading material in situ. The potential of the Langmuir monolayer degradation technique as a predictive tool for implant degradation when combined with computational methods is outlined, and related open questions and strategies to overcome these challenges are pointed out.

中文翻译：

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Langmuir单层膜作为研究可生物降解聚合物植入材料的工具

Langmuir单层膜为分析可生物降解聚合物材料的降解行为提供了一种快速而优雅的途径。与散装材料相比，（部分降解的）材料中反应物和反应产物的扩散运输在空气-水界面处可以忽略不计，从而使得在不到一天的时间内进行分子降解动力学研究成为可能，而在某些情况下，几分钟后，与耗时数年的散装材料实验相反。可直接观察到聚合物材料生物降解行为的几个方面，例如与生物分子和降解产物的相互作用。利用表面敏感的仪器技术扩展该技术可以评估形态，化学成分，以及原位降解材料的机械性能。概述了Langmuir单层降解技术与计算方法结合时作为植入物降解的预测工具的潜力，并指出了克服这些挑战的相关开放性问题和策略。