MicroRNAs, a subset of non-coding RNAs, are present in virtually all tissues including body fluids and are global regulators of the transcriptome. In view of the expanding number of microRNAs and the large number of gene targets that each microRNA can potentially regulate, they have been compared to hormones in the scope of their effects. MicroRNA have been implicated as biomarkers for several diseases including stroke, as well as chronic conditions that are associated with stroke. Recent research has focused on manipulating miRNA to improve stroke outcomes. Although several miRNAs have been shown to have neuroprotective properties, the overwhelming majority of these studies have employed only male animals. This review will focus on two miRNAs, Let7f and mir363-3p, whose effectiveness as a stroke neuroprotectant is sex-specific.

中文翻译：

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miRNA的性别差异可治疗缺血性中风。

MicroRNA是非编码RNA的子集，几乎存在于包括体液在内的所有组织中，并且是转录组的整体调节剂。鉴于microRNA的数量不断增加，而且每种microRNA都可能调控大量的基因靶标，因此已将它们与激素的作用范围进行了比较。MicroRNA被认为是包括中风以及与中风相关的慢性疾病在内的几种疾病的生物标志物。最近的研究集中在操纵miRNA来改善卒中预后。尽管已经证明了几种miRNA具有神经保护特性，但是这些研究中绝大多数都只使用了雄性动物。这项审查将侧重于两个miRNA，Let7f和mir363-3p，它们作为中风神经保护剂的有效性是性别特异性的。