Solution blow spinning (SBS) has emerged as a rapid and scalable technique for the production of polymeric and ceramic materials into micro-/nanofibers. Here, SBS was employed to produce submicrometer fibers of regenerated silk fibroin (RSF) from Bombyx mori (silkworm) cocoons based on formic acid or aqueous systems. Spinning in the presence of vapor permitted the production of fibers from aqueous solutions, and high alignment could be obtained by modifying the SBS setup to give a concentrated channeled airflow. The combination of SBS and a thermally induced phase separation technique (TIPS) resulted in the production of macro-/microporous fibers with 3D interconnected pores. Furthermore, a coaxial SBS system enabled a pH gradient and kosmotropic salts to be applied at the point of fiber formation, mimicking some of the aspects of the natural spinning process, fostering fiber formation by self-assembly of the spinning dope. This scalable and fast production of various types of silk-based fibrous scaffolds could be suitable for a myriad of biomedical applications.

中文翻译：

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溶液吹纺生产的再生丝素蛋白的多孔，排列和仿生纤维

固溶吹纺（SBS）已成为一种快速且可扩展的技术，用于将聚合物和陶瓷材料生产成微纤维/纳米纤维。在这里，SBS被用于从家蚕中生产再生丝素蛋白（RSF）的亚微米纤维。（蚕）基于甲酸或水性体系的茧。在蒸气存在下进行纺丝可以从水溶液中生产纤维，并且可以通过修改SBS设置以提供集中的引导气流来获得高度对齐。SBS和热诱导相分离技术（TIPS）的组合导致了具有3D互连孔的大孔/微孔纤维的生产。此外，同轴SBS系统能够在纤维形成时应用pH梯度和同质盐，从而模仿自然纺丝工艺的某些方面，通过纺丝原液的自组装促进纤维形成。各种类型的基于丝绸的纤维支架的这种可扩展且快速的生产可能适用于多种生物医学应用。