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Engineering with Biomolecular Motors
Accounts of Chemical Research ( IF 18.3 ) Pub Date : 2018-10-30 00:00:00 , DOI: 10.1021/acs.accounts.8b00296
Henry Hess 1 , Gadiel Saper 1
Affiliation  

Biomolecular motors, such as the motor protein kinesin, can be used as off-the-shelf components to power hybrid nanosystems. These hybrid systems combine elements from the biological and synthetic toolbox of the nanoengineer and can be used to explore the applications and design principles of active nanosystems. Efforts to advance nanoscale engineering benefit greatly from biological and biophysical research into the operating principles of motor proteins and their biological roles. In return, the process of creating in vitro systems outside of the context of biology can lead to an improved understanding of the physical constraints creating the fitness landscape explored by evolution. However, our main focus is a holistic understanding of the engineering principles applying to systems integrating molecular motors in general.

中文翻译:

生物分子电机工程

生物分子马达,例如马达蛋白驱动蛋白,可以用作为混合纳米系统提供动力的现成组件。这些混合系统结合了纳米工程师的生物和合成工具箱中的元素,可用于探索活性纳米系统的应用和设计原理。推进纳米级工程的努力得益于对运动蛋白及其生物学作用的生物学原理和生物物理研究。作为回报,在生物学背景之外创建体外系统的过程可以导致人们更好地理解物理限制,从而通过进化探索出适合的环境。但是,我们的主要重点是对应用于集成分子电动机的系统的工程原理的整体理解。
更新日期:2018-10-30
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