Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro and in vivo, however little attention has been paid to the cellular functioning of the surviving cells. We report here new evidence demonstrating the onset of thermally triggered differentiation in osteosarcoma cancer cells that survive magnetic hyperthermia treatment. This raises the possibility that in addition to causing cell death, magnetic hyperthermia could induce surviving cancer cells to form more mature cell types and thereby inhibit their capacity to self-renew. Such processes could prove to be as important as cell death when considering magnetic hyperthermia for treating cancer.

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磁热疗法引发癌细胞分化的潜力

磁热疗是一种潜在的癌症治疗技术，它利用磁性纳米颗粒产生的热量杀死癌细胞。许多研究已经表明，磁热疗是在两个杀死癌细胞有效的体外和体内然而，对存活细胞的细胞功能的关注却很少。我们在此报告新证据，证明在磁热疗中幸存的骨肉瘤癌细胞中热触发分化的开始。这增加了这样的可能性，除了引起细胞死亡外，磁热疗还可以诱导存活的癌细胞形成更多成熟的细胞类型，从而抑制其自我更新的能力。当考虑使用磁热疗法治疗癌症时，此类过程可能与细胞死亡一样重要。