Autoinflammatory diseases are rare group of conditions manifested by recurrent fevers, systemic inflammation, and dysfunctions of the innate immune system. These conditions are characterized by overproduction or lack of inhibition of various cytokines, and the advent of biologic drugs that block specific cytokines involved in these conditions has revolutionized their treatment. In this review, I will discuss the most common autoinflammatory conditions of adulthood including familial Mediterranean fever (FMF), cryopyrin-associated periodic syndrome (CAPS), mevalonate kinase deficiency/hyperimmunoglobulinemia D Syndrome (MKD/HIDS), TNF receptor-associated autoinflammatory syndrome (TRAPS), and systemic juvenile idiopathic arthritis/adult-onset Still's disease (SJIA/AOSD). I will discuss how IL-1, IL-6, IL-18, and TNF play pathogenic roles in these conditions and will review the evidence behind cytokine blockade for these diseases. Throughout the paper, I will reflect on gaps in knowledge of autoinflammatory diseases and will highlight the latest advances and newest drugs in development.

中文翻译：

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靶向细胞因子来治疗自身炎症性疾病。

自身炎症性疾病是罕见的一组疾病，表现为反复发烧，全身性炎症和先天免疫系统功能障碍。这些病症的特征在于多种细胞因子的过度生产或缺乏抑制，并且阻断与这些病症有关的特定细胞因子的生物药物的出现彻底改变了它们的治疗方法。在这篇综述中，我将讨论成年期最常见的自身炎性疾病，包括家族性地中海热（FMF），冷冻蛋白相关的周期性综合征（CAPS），甲羟戊酸激酶缺乏症/高免疫球蛋白血症D综合征（MKD / HIDS），TNF受体相关的自身炎性综合征（TRAPS）和系统性幼年特发性关节炎/成年Still病（SJIA / AOSD）。我将讨论IL-1，IL-6，IL-18，TNF和TNF在这些情况下发挥致病作用，并将审查这些疾病的细胞因子阻滞作用背后的证据。在整篇论文中，我将反思自身炎症性疾病的知识差距，并将重点介绍最新的进展和最新的药物开发。