Objective

Measurement of treatment outcomes in childhood depression has traditionally focused on assessing symptoms from the clinician’s perspective, without exploring other outcome domains or considering young people’s perspectives. This systematic review explored the extent to which multidimensional and multi-informant outcome measurements have been used in clinical research for adolescent depression in the past decade and how patterns have evolved over time.

Method

Embase, Medline, and PsycINFO were searched, and studies that were published from 2007 through 2017 and assessed the effectiveness of treatments or service provision for adolescent depression were included. Of 7,483 studies screened, 95 met the inclusion criteria and were included for data extraction and analysis.

Results

Ten outcomes domains were identified, 2 of which were assessed on average using 4 outcome measures. Most studies (94%) measured symptoms, followed by functioning (52%). Other domains such as personal growth, relationships, quality of life, and service satisfaction were each considered by less than 1 in 10 studies. Youth self-report was considered by 54% but tended to focus on secondary outcomes. Multidimensional and multi-informant measurements were more frequent in studies published since 2015.

Conclusion

Recent clinical research continues to prioritize symptoms measurement based on clinician report and has not yet fully embraced multidimensional and multi-informant approaches. In the context of significant policy shifts toward patient-centered and evidence-based care, measuring what matters most to patients has become a priority, but this is not yet widely reflected in clinical research.

中文翻译：

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评论：什么结果很重要？2007年至2017年期间针对青少年抑郁症测得的结果

客观的

传统上，对儿童抑郁症的治疗结果进行测量的重点是从临床医生的角度评估症状，而没有探索其他结果领域或考虑年轻人的观点。这项系统的综述探讨了过去十年来在青少年抑郁症临床研究中使用多维和多信息结局测量的程度，以及随着时间的推移，模​​式如何演变。

方法

检索了Embase，Medline和PsycINFO，并纳入了2007年至2017年发表的评估青少年抑郁症的治疗或服务有效性的研究。在筛选的7,483项研究中，有95项符合纳入标准，被纳入数据提取和分析。

结果

确定了10个结果域，其中2个使用4个结果度量进行了平均评估。大多数研究（94％）测量了症状，其次是功能（52％）。其他领域，例如个人成长，人际关系，生活质量和服务满意度，均少于十分之一。青年自我报告占54％，但往往侧重于次要结果。自2015年以来发表的研究中，多维和多信息量度测量更为频繁。

结论

最近的临床研究继续根据临床医生的报告确定症状测量的优先次序，并且尚未完全采用多维和多信息方法。在重大政策转向以患者为中心和基于证据的护理的背景下，衡量对患者最重要的事情已成为当务之急，但这尚未在临床研究中得到广泛反映。