This work investigates the thermal stability of bacteriocin nisin in polylactide (PLA) and polylactide/polyethylene glycol (PLA/PEG) blends at temperatures of 90 °C–180 °C. The samples were prepared by solvent cast technique and characterized according to their mechanical and thermal properties. Research on the thermal stability of nisin in the PLA and PLA/PEG systems was carried out by exposing the given films to various temperatures (90 °C, 120 °C, 160 °C, and 180 °C) for a duration of up to 48 h. Assessment of the antibacterial activity of the samples was carried out by the agar diffusion method against Micrococcus luteus, while structural analysis involved the use of high-performance liquid chromatography with mass detection. Structural changes in the polymer matrix were evaluated by gel permeation chromatography and scanning electron microscopy. The results showed that nisin retained almost 70% of its antimicrobial activity in the PLA matrix, even after treatment at 160 °C for 15 min. The presence of PEG significantly enhanced the degradation of nisin above 120 °C.

这项工作研究了细菌素乳链菌肽在90°C–180°C的温度下在聚丙交酯（PLA）和聚丙交酯/聚乙二醇（PLA / PEG）混合物中的热稳定性。样品通过溶剂浇铸技术制备，并根据其机械性能和热性能进行表征。乳酸链球菌素在PLA和PLA / PEG系统中的热稳定性的研究是通过将给定的薄膜暴露于各种温度下（90°C，120°C，160°C和180°C）并持续至48小时 通过琼脂扩散法评估样品对黄曲霉的抗菌活性。，而结构分析则涉及使用具有质量检测功能的高效液相色谱仪。通过凝胶渗透色谱法和扫描电子显微镜评价聚合物基质中的结构变化。结果表明，即使在160°C处理15分钟后，乳链菌肽仍能将其抗菌活性保留在PLA基质中近70％。PEG的存在在120°C以上会显着增强乳链菌肽的降解。