Abstract This paper reports the development and application of a disposable sensor for the individual and simultaneous voltammetric determination of dopamine (DA) and N-acetyl-p-aminophenol (APAP). The sensor was fabricated by drop-coating graphene nanoplatelets (GNPs)-Nafion (Naf) nanocomposite onto the working area of a screen-printed electrode (SPE). The sensor, designated as GNPs-Naf/SPE, was characterized by scanning electron microscopy (SEM), Raman spectroscopy, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Differential pulse voltammetry (DPV) was used to simultaneously analyze DA and APAP in their binary mixtures. It showed excellent selectivity and sensitivity toward both compounds with limit of detection of 0.13 µM and 0.25 µM (S/N = 3) for DA and APAP, respectively. The performance of the sensor was evaluated by analyzing the compounds in human urine samples, and the recoveries were found to be well over 97.0%.

中文翻译：

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基于石墨烯纳米血小板的传感器用于检测尿液中的多巴胺和 N-乙酰基-对氨基苯酚

摘要 本文报道了一种一次性传感器的开发和应用，用于单独和同时伏安法测定多巴胺 (DA) 和 N-乙酰基对氨基苯酚 (APAP)。该传感器是通过将石墨烯纳米片（GNP）-Nafion（Naf）纳米复合材料滴涂到丝网印刷电极（SPE）的工作区域来制造的。该传感器被命名为 GNPs-Naf/SPE，通过扫描电子显微镜 (SEM)、拉曼光谱、电化学阻抗谱 (EIS) 和循环伏安法 (CV) 进行表征。差分脉冲伏安法 (DPV) 用于同时分析二元混合物中的 DA 和 APAP。它对两种化合物均显示出出色的选择性和灵敏度，DA 和 APAP 的检测限分别为 0.13 µM 和 0.25 µM (S/N = 3)。