Five undescribed xanthones, 4-methoxypyranojacareubin, 4-hydroxy-3-prenylpyranoxanthone, 1-hydroxy-5,7-dimethoxyxanthone, 5-hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone, together with thirty-three known xanthones were isolated from the roots of Mesua ferrea L. The structures of all isolated xanthones were elucidated based on spectroscopic methods. 5-Hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone were also confirmed by X-ray diffraction data. In addition, the isolated compounds were determined for antibacterial, antioxidant and cytotoxic activities. The known 1,5,6-trihydroxyxanthone showed cytotoxicity against A375, PC-3 and HaCaT cell lines with IC50 values of 5.73 μg/mL, 5.93 μg/mL and 8.94 μg/mL, respectively.

中文翻译：

---

来自 Mesua ferrea L. 根的细胞毒性氧杂蒽酮。

五种未描述的氧杂蒽酮、4-甲氧基吡喃茉莉酮、4-羟基-3-异戊二烯基吡喃氧杂蒽酮、1-羟基-5,7-二甲氧基氧杂蒽酮、5-羟基-1,6,7-三甲氧基氧杂蒽酮和 2-羟基-1,5-二甲氧基氧杂蒽酮，以及从 Mesua ferrea L 的根中分离出 33 种已知的氧杂蒽酮。所有分离的氧杂蒽酮的结构都基于光谱方法阐明。X 射线衍射数据也证实了 5-羟基-1,6,7-三甲氧基氧杂蒽酮和 2-羟基-1,5-二甲氧基氧杂蒽酮。此外，还测定了分离出的化合物的抗菌、抗氧化和细胞毒活性。已知的 1,5,6-三羟基呫吨酮对 A375、PC-3 和 HaCaT 细胞系具有细胞毒性，IC50 值分别为 5.73 μg/mL、5.93 μg/mL 和 8.94 μg/mL。