The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.

受体的淋巴细胞活化激活分子（SLAM）家族（SLAMF）是属于CD2家族的一组受体。它由在许多造血细胞上表达的几个成员组成。大多数受体以同源的方式与邻近细胞相互作用。它们的分布和结合特性，以及同时充当激活受体和抑制受体的能力，使其成为免疫系统调节的关键参与者。已经广泛研究了几种SLAM家族受体。这篇综述主要针对CD244（2B4或SLAMF4）和CD48，特别是由过敏的关键细胞，肥大细胞和嗜酸性粒细胞表达的CD44。