A fierce dispute has arisen between the supporters of phenotypic and target-focused screening regarding which path grants the higher probability of successful drug development. A chance to reconcile these two approaches lies in successful target deconvolution (TD) after phenotypic screens. But, despite the panoply of available in vitro TD methods, the task of matching a phenotypically active compound with a biomolecular target remains challenging. Consequently, this review details the latest developments of in silico techniques that expedite TD. Ultimately, the deconvoluted target allows us to reap the benefits of the phenotypic and target-focused approaches.

在表型和靶标筛选的支持者之间出现了激烈的争执，关于哪种途径赋予成功药物开发更高的可能性。调和这两种方法的机会在于表型筛选后成功的靶标去卷积（TD）。但是，尽管有可用的体外TD方法，但将表型活性化合物与生物分子靶标相匹配的任务仍然具有挑战性。因此，本次审查详细介绍了可加快TD速度的计算机技术的最新发展。最终，解卷积的目标使我们能够从表型和目标集中的方法中受益。