Momordica charantia L. (Cucurbitaceae) is a popular vegetable and traditional folk medicine, that has been used for hundreds of years. In this study, three undescribed cucurbitane-type triterpene glycosides furpyronecucurbitane A, goyaglycoside I and charantagenin F along with nine known compounds were isolated from the immature fruit of Momordica charantia L. Their structures were identified on the basis of extensive 1D, 2D NMR and HRESIMS spectroscopy analysis. All isolated compounds were examined for their anti-hepatic fibrosis activity against murine hepatic stellate cells (t-HSC/Cl-6) and anti-hepatoma activity against two kinds of liver cancer cell lines (HepG2 and Hep3B). Among them, karaviloside III exhibited excellent inhibitory activity against activated t-HSC/Cl-6 cells and cytotoxic activity against Hep3B and HepG2 cell lines with IC50 values of 3.74 ± 0.13, 16.68 ± 2.07 and 4.12 ± 0.36 μM, respectively, which may potential to be developed as a chemotherapy agent for treatment hepatic fibrosis or carcinoma and protection against both diseases.

中文翻译：

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苦瓜果实中的葫芦烷三萜类化合物及其抗肝纤维化和抗肝癌活性

苦瓜（Cucurbitaceae）是一种流行的蔬菜和传统民间药物，已经使用了数百年。在本研究中，从苦瓜未成熟果实中分离出三种未描述的葫芦型三萜糖苷呋喃酮 A、goyaglycoside I 和 charantagenin F 以及九种已知化合物。它们的结构基于广泛的 1D、2D NMR 和 HRESIMS 进行鉴定光谱分析。检查了所有分离的化合物对鼠肝星状细胞 (t-HSC/Cl-6) 的抗肝纤维化活性和对两种肝癌细胞系 (HepG2 和 Hep3B) 的抗肝癌活性。他们之中，