Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates,Chemical Communications

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Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates
Chemical Communications ( IF 4.9 ) Pub Date : 2018-10-22 , DOI: 10.1039/c8cc07481j
Zhihua Cai _{1,

2,

3,

4,

5} , Shangda Li _{1,

2,

3} , Yuzhen Gao _{1,

2,

3} , Lei Fu _{1,

2,

3} , Gang Li _{1,

2,

3,

4,

5}

Affiliation

A protocol of Pd(II)-catalyzed, weak bidentate directing group assisted β-C(sp³)–H activation/cross-coupling with organoboron reagents has been achieved, affording arylation of aliphatic acid derivatives that contain α-hydrogen atoms in moderate to good yields. The potential of this method for an asymmetric β-C(sp³)–H arylation via desymmetrization was also presented.

中文翻译：

弱的双齿螯合基团有助于脂肪酸衍生物中的C（sp ³）-H键与芳基三氟硼酸酯交叉偶联

已实现了由Pd（II）催化的弱双齿指导基团辅助的β-C（sp ³）-H活化/与有机硼试剂交叉偶联的方案，使含α-氢原子的脂肪族酸衍生物芳构化高产。还介绍了该方法通过去对称化进行不对称β-C（sp ³）-H芳构化的潜力。

更新日期：2018-11-08

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