Multiple pregnancies and air pollution in moderately polluted cities: Is there an association between air pollution and fetal growth?,Environment International

当前位置： X-MOL 学术 › Environ. Int. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Multiple pregnancies and air pollution in moderately polluted cities: Is there an association between air pollution and fetal growth?
Environment International ( IF 11.8 ) Pub Date : 2018-10-20 , DOI: 10.1016/j.envint.2018.10.015
Anne-Sophie Mariet , Frédéric Mauny , Sophie Pujol , Gérard Thiriez , Paul Sagot , Didier Riethmuller , Mathieu Boilleaut , Jérôme Defrance , Hélène Houot , Anne-Laure Parmentier , Marie Vasseur-Barba , Eric Benzenine , Catherine Quantin , Nadine Bernard

Background

Multiple pregnancies (where more than one fetus develops simultaneously in the womb) are systematically excluded from studies of the impact of air pollution on pregnancy outcomes. This study aims to analyze, in a population of multiple pregnancies, the relationship between fetal growth restriction (FGR), small for gestational age (SGA) and exposure to air pollution in moderately polluted cities.

Methods

All women with multiple pregnancies living in the city of Besançon or in the urban area of Dijon and who delivered at a university hospital between 2005 and 2009 were included. FGR and SGA were obtained from medical records. Outdoor residential nitrogen dioxide (NO₂) exposure was assessed using the mother's address, considering a 50 m radius buffer over the following defined pregnancy periods: each trimester, entire pregnancy and two months before delivery. Logistic regression analyses were performed.

Results

This study included 249 multiple pregnancies with 506 newborns. The median of NO₂ concentration considering a 50 m radius buffer during entire pregnancy was 23.1 μg/m³ (minimum at 10.1 μg/m³ and maximum at 46.7 μg/m³). No association was observed between NO₂ and SGA whatever the pregnancy period (the odds ratio (OR) range 0.78 to 0.88). Regarding FGR, the OR associated with an increase of 10 μg/m³ of NO₂ exposure during entire pregnancy was 1.52 (95% Confidence Interval (CI): 1.02–2.26). Similar results were observed for NO₂ exposure during the various pregnancy periods.

Conclusions

These results are in line with an association between NO₂ and fetal growth in multiple pregnancies for an exposure mostly below the threshold set out in European legislation.

中文翻译：

中度污染城市的多次怀孕和空气污染：空气污染与胎儿生长之间是否存在关联？

背景

在空气污染对妊娠结局的影响研究中，系统地排除了多次怀孕（子宫内同时发育多个胎儿）。这项研究旨在分析多胎妊娠人群中胎儿生长受限（FGR），胎龄小（SGA）与中度污染城市暴露于空气污染之间的关系。

方法

包括所有在贝桑松市或第戎市区居住并于2005年至2009年之间在大学医院分娩的孕妇。FGR和SGA是从病历中获得的。使用母亲的地址评估室外住宅二氧化氮（NO ₂）的暴露，考虑在以下定义的怀孕期间（每个孕期，整个怀孕和分娩前两个月）使用50 m半径的缓冲区。进行逻辑回归分析。

结果

这项研究包括249例多胎妊娠与506例新生儿。在整个怀孕期间考虑使用50 m半径缓冲液的NO ₂浓度中位数为23.1μg/ m ³（最小为10.1μg/ m ³，最大为46.7μg/ m ³）。无论妊娠期如何，NO ₂与SGA之间均未发现关联（比值比（OR）在0.78至0.88之间）。关于FGR，整个妊娠期间与NO ₂暴露增加10μg/ m ³有关的OR为1.52（95％可信区间（CI）：1.02-2.26）。在各个怀孕期间，NO ₂暴露观察到相似的结果。