Tactile sensors capable of perceiving biophysical signals such as force, pressure, or strain have attracted extensive interest for versatile applications in electronic skin, noninvasive healthcare, and biomimetic prostheses. Despite these great achievements, they are still incapable of detecting bio/chemical signals that provide even more meaningful and precise health information due to the lack of efficient transduction principles. Herein, a tactile chemomechanical transduction strategy that enables the tactile sensor to perceive bio/chemical signals is proposed. In this methodology, pyramidal tactile sensors are linked with biomarker‐induced gas‐producing reactions, which transduce biomarker signals to electrical signals in real time. The method is advantageous as it enhances electrical signals by more than tenfold based on a triple‐step signal amplification strategy, as compared to traditional electrical biosensors. It also constitutes a portable and general platform capable of quantifying a wide spectrum of targets including carcinoembryonic antigen, interferon‐γ, and adenosine. Such tactile chemomechanical transduction would greatly broaden the application of tactile sensors toward bio/chemical signals perception which can be used in ultrasensitive portable biosensors and chemical‐responsive chemomechanical systems.

中文翻译：

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基于弹性微结构阵列的触觉化学机械传导可增强便携式生物传感器的灵敏度

能够感知生物物理信号（例如力，压力或应变）的触觉传感器引起了广泛的兴趣，广泛应用于电子皮肤，非侵入式医疗保健和仿生假体中。尽管取得了这些巨大成就，但由于缺乏有效的转导原理，它们仍无法检测提供更有意义和更精确的健康信息的生物/化学信号。在此，提出了一种使触觉传感器能够感知生物/化学信号的触觉化学机械转导策略。在这种方法中，金字塔型触觉传感器与生物标志物引起的产气反应相关联，从而将生物标志物信号实时转换为电信号。与传统的电生物传感器相比，该方法具有优势，因为它基于三步信号放大策略将电信号增强了十倍以上。它也构成了一个便携式的通用平台，能够定量分析多种靶标，包括癌胚抗原，干扰素-γ和腺苷。这种触觉化学机械转导将极大地扩大触觉传感器在生物/化学信号感知方面的应用，可用于超灵敏便携式生物传感器和化学反应性化学机械系统中。