Synthesis of strontium-doped hydroxyapatite from Mercenaria clam shells has been carried out by hydrothermal method. The doping of bioceramic, processed from biogenic resources is mostly unexplored. The objective is to understand the effect of strontium (Sr) incorporation on phase stability, sintering behaviour, mechanical properties and cytotoxicity of hydroxyapatite (HAp) derived from clam shells. The different molar concentrations of Sr, varies from 10, 30, 50, 70% of Ca, were substituted into the HAp. The synthesized powders were sintered at 1200 °C in air. The as synthesized powders and sintered specimens were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and high resolution transmission electron microscopy. The crystallite size and cell parameters of sintered specimens were analyzed from XRD. The XRD of hydrothermally synthesized powders mostly matched with HAp with slight shifting due to Sr doping. However, some distinct Sr based compounds were also observed where Sr substitution is more that 50% of Ca. The XRD of sintered specimen showed increasing β-tricalcium phosphate (β-TCP) phase with Sr substitution. The sintered density of solid samples gradually increased from 3.04 g/cc to 3.50 g/cc and surface energy decreased with increasing Sr substitution. Similarly, microhardness, fracture toughness and nanohardness of solid samples found to be enhanced with Sr substitution. The elastic modulus gradually increased from 130 to 137 GPa for HAp and Sr substituted HAp (70% of Ca). The in vitro cytotoxicity of sintered specimen against mouse osteoblast cell line showed that all the samples were nontoxic. However cell proliferation found low for the solid samples containing more than 50% Sr substitution.

从Mercenaria合成锶掺杂的羟基磷灰石蛤壳已经通过水热法进行了。由生物资源加工而成的生物陶瓷的掺杂大部分尚未开发。目的是了解锶（Sr）的掺入对蛤壳中羟基磷灰石（HAp）的相稳定性，烧结性能，机械性能和细胞毒性的影响。Sr的不同摩尔浓度（从Ca的10％，30％，50％，70％不等）被替换为HAp。合成的粉末在空气中于1200°C烧结。使用X射线衍射（XRD），傅立叶变换红外光谱（FTIR）和高分辨率透射电子显微镜对合成后的粉末和烧结样品进行表征。用XRD分析了烧结样品的微晶尺寸和晶胞参数。水热合成粉末的XRD值几乎与HAp相匹配，并且由于Sr的掺杂而发生了轻微的偏移。但是，还观察到一些不同的基于Sr的化合物，其中Sr取代的含量超过Ca的50％。烧结后的样品的X射线衍射显示出β-磷酸三钙（β-TCP）相被Sr取代增加。固体样品的烧结密度从3.04 g / cc逐渐增加到3.50 g / cc，并且表面能随着Sr置换的增加而降低。类似地，发现固态样品的显微硬度，断裂韧性和纳米硬度可通过Sr替代得到增强。HAp和Sr取代的HAp（Ca的70％）的弹性模量从130 GPa逐渐增加到137 GPa。烧结样品对小鼠成骨细胞系的体外细胞毒性表明，所有样品均无毒。