Attention deficit hyperactivity disorder (ADHD), bipolar disorder (BP) and schizophrenia (SCZ) are complex psychiatric disorders. We conducted a large-scale integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) datasets. The GWAS data of ADHD (including 20,183 cases and 35,191 controls), BP (including 7481 cases and 9250 controls) and SCZ (including 36,989 cases and 113,075 controls) were derived from published GWAS. Life course consistent meQTLs dataset was obtained from a longitudinal meQTLs analysis of 1018 mother–child pairs. Gene prioritization, pathway and tissue/cell type enrichment analysis were conducted by DEPICT. We identified multiple genes and pathways with common or disease specific effects, such as NISCH (P = 9.87 × 10⁻³ for BP and 2.49 × 10⁻⁶ for SCZ), ST3GAL3 (P = 1.19 × 10⁻² for ADHD), and KEGG_MAPK_SIGNALING_PATHWAY (P = 1.56 × 10⁻³ for ADHD, P = 4.71 × 10⁻² for BP, P = 4.60 × 10⁻⁴ for SCZ). Our study provides novel clues for understanding the genetic mechanism of ADHD, BP and SCZ.

注意缺陷多动障碍（ADHD），躁郁症（BP）和精神分裂症（SCZ）是复杂的精神病性疾病。我们进行了全基因组关联研究（GWAS）和生命历程一致的甲基化定量特征位点（meQTLs）数据集的大规模综合分析。ADHD（包括20,183例病例和35,191例对照），BP（包括7481例病例和9250例对照）和SCZ（包括36,989例病例和113,075例对照）的GWAS数据来自已发布的GWAS。生命周期一致的meQTLs数据集是从对1018对母子的纵向meQTLs分析中获得的。基因优先级，途径和组织/细胞类型富集分析由DEPICT进行。我们确定了具有共同或特定疾病影响的多种基因和途径，例如NISCH（P = 9.87×10 ^-3为BP和2.49×10 ^-6为SCZ），ST3GAL3（P  = 1.19×10 ^-2为ADHD），和KEGG_MAPK_SIGNALING_PATHWAY（P  = 1.56×10 ^-3为ADHD，P  = 4.71×10 ^-对于BP为²，对于SCZ为P  = 4.60×10 ^-4）。我们的研究为理解ADHD，BP和SCZ的遗传机制提供了新的线索。