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Single-molecule protein sensing in a nanopore: a tutorial
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2018-10-17 00:00:00 , DOI: 10.1039/c8cs00106e
Nitinun Varongchayakul 1, 2, 3, 4 , Jiaxi Song 1, 2, 3, 4 , Amit Meller 1, 1, 2, 3, 4 , Mark W. Grinstaff 1, 2, 3, 4, 5
Affiliation  

Proteins are the structural elements and machinery of cells responsible for a functioning biological architecture and homeostasis. Advances in nanotechnology are catalyzing key breakthroughs in many areas, including the analysis and study of proteins at the single-molecule level. Nanopore sensing is at the forefront of this revolution. This tutorial review provides readers a guidebook and reference for detecting and characterizing proteins at the single-molecule level using nanopores. Specifically, the review describes the key materials, nanoscale features, and design requirements of nanopores. It also discusses general design requirements as well as details on the analysis of protein translocation. Finally, the article provides the background necessary to understand current research trends and to encourage the identification of new biomedical applications for protein sensing using nanopores.

中文翻译:

纳米孔中的单分子蛋白质感测:教程

蛋白质是负责功能性生物结构和体内平衡的细胞的结构元件和机械。纳米技术的进步正在催化许多领域的重大突破,包括在单分子水平上对蛋白质的分析和研究。纳米孔感测技术是这场革命的最前沿。本教程概述为读者提供了使用纳米孔在单分子水平上检测和表征蛋白质的指南和参考。具体地说,本综述描述了纳米孔的关键材料,纳米级特征和设计要求。它还讨论了一般设计要求以及有关蛋白质转运分析的详细信息。最后,
更新日期:2018-10-17
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