An efficient four-component radical cascade reaction of alkenes, enabled by an EDA complex between Togni's reagent and Hantzsch ester, has been reported. This operationally simple protocol demonstrates excellent selectivity, which is dominated by the innate polar effect, providing facile access to important δ-CF₃ carbonyls under mild conditions. To further demonstrate the wide synthetic utility of this method, a three-step synthesis of CF₃-naftidrofuryl has been successfully conducted.

中文翻译：

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电子给体-受体配合物使烯烃的四组分自由基级联三氟甲基化反应

据报道，通过Togni试剂和Hantzsch酯之间的EDA络合物，烯烃可以进行有效的四组分自由基级联反应。这种操作简单协议表明优异的选择性，这是由先天性极性效应支配，提供到重要δ-CF容易访问_3个温和的条件下羰基化合物。为了进一步证明该方法的广泛合成效用，已经成功地进行了CF _3-萘基呋喃基的三步合成。