Long noncoding RNAs (lncRNAs) are closely associated with the molecular mechanisms underlying cancer development, and it would be highly useful to study their expression and mechanisms in cervical cancer too. The current study investigated lncRNA799 expression in cervical cancer in order to determine its clinical importance in the progression of cervical cancer. lncRNA799 expression was studied in 218 cervical cancer samples. Expression of lncRNA799 was significantly higher in the cervical cancer tissue than in the adjacent normal tissue. Overexpression of lncRNA799 was found to have a significant correlation with FIGO stage, SCC-Ag level, and lymphatic metastasis, and it was also associated with poor survival. Ectopic expression of lncRNA799 promoted the metastasis of SiHa cells, whereas lncRNA799 knockdown had an inhibitory effect on metastasis. Western blot analysis demonstrated that lncRNA799 promotes the expression of transducing β-like protein 1-related protein (TBL1XR1), and that lncRNA799 and TBL1XR1 expression show strong correlation in cervical cancer. Moreover, lncRNA799 modulated the expression of TBL1XR1 by acting as a competitive endogenous RNA (ceRNA) for miR-454-3P. The results indicate that lncRNA799 could be used as a novel marker of cervical cancer prognosis. Thus, targeting the ceRNA network involving lncRNA799 could be a potential treatment strategy against cervical cancer.

长非编码RNA（lncRNA）与癌症发展的分子机制密切相关，研究其在宫颈癌中的表达及其机制也将非常有用。本研究调查了lncRNA799在宫颈癌中的表达，以确定其在宫颈癌进展中的临床重要性。在218例宫颈癌样本中研究了lncRNA799的表达。在宫颈癌组织中，lncRNA799的表达明显高于相邻的正常组织。发现lncRNA799的过表达与FIGO分期，SCC-Ag水平和淋巴结转移有显着相关性，并且还与不良的存活率相关。lncRNA799的异位表达促进了SiHa细胞的转移，而lncRNA799的抑制对转移有抑制作用。蛋白质印迹分析表明，lncRNA799促进了转导的β样蛋白1相关蛋白（TBL1XR1）的表达，并且lncRNA799和TBL1XR1的表达在宫颈癌中显示出强相关性。此外，lncRNA799通过充当miR-454-3P的竞争性内源RNA（ceRNA）来调节TBL1XR1的表达。结果表明lncRNA799可作为宫颈癌预后的新指标。因此，靶向涉及lncRNA799的ceRNA网络可能是针对宫颈癌的潜在治疗策略。lncRNA799通过充当miR-454-3P的竞争性内源RNA（ceRNA）来调节TBL1XR1的表达。结果表明lncRNA799可作为宫颈癌预后的新指标。因此，靶向涉及lncRNA799的ceRNA网络可能是针对宫颈癌的潜在治疗策略。lncRNA799通过充当miR-454-3P的竞争性内源RNA（ceRNA）来调节TBL1XR1的表达。结果表明lncRNA799可作为宫颈癌预后的新指标。因此，靶向涉及lncRNA799的ceRNA网络可能是针对宫颈癌的潜在治疗策略。