Methylation is a well‐known structural modification in organic and medicinal chemistry. This review summarizes recent advances in methylation by categorizing specific methylation reagents. The challenges of mono N‐methylation of aliphatic amines and N‐methylation of peptides are discussed. This review will be useful for chemists wanting to select the appropriate reagents for methylation chemistry. Based on the large diversity of methylation reagents and their wide scope, this review also broadens perspectives on which strategies to select for utilizing a particular methylation, resulting in an increased flexibility in synthetic route planning.

中文翻译：

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甲基化的最新进展：甲基化试剂的选择指南

甲基化是有机化学和药物化学中众所周知的结构修饰。这篇综述通过分类特定的甲基化试剂总结了甲基化的最新进展。讨论了脂族胺单N-甲基化和肽N-甲基化的挑战。这篇综述对于希望为甲基化化学选择适当试剂的化学家将是有用的。基于甲基化试剂的广泛多样性及其广泛的适用范围，本综述还拓宽了选择使用哪种特定甲基化策略的视野，从而增加了合成路线规划的灵活性。