Prebiotic evolution is the stage that is assumed to have taken place prior to the emergence of the first living entities, during which time the abiotic synthesis of monomers, oligomers, and supramolecular systems that led to the hypothesized RNA world occurred. In this Perspective, the success of one-pot Miller–Urey type synthesis of organic compounds is compared with the multipot syntheses developed within the framework of systems chemistry, which attempts to demonstrate that RNA could have been formed directly in the primitive environment. The prebiotic significance of liquid-crystal ordering of nucleic acid oligomers and self-organizing assemblages of RNA and DNA that are formed in the absence of membranes or mineral matrices is also addressed.

中文翻译：

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益生元的进化和核酸的自组装

益生元进化是假设在第一个生物实体出现之前发生的阶段，在此期间，发生了导致假想的RNA世界的单体，低聚物和超分子系统的非生物合成。在此观点中，将一锅法的Miller–Urey型有机化合物合成的成功与在系统化学框架内开发的多锅法合成进行了比较，后者试图证明RNA可以直接在原始环境中形成。还讨论了在没有膜或矿物基质的情况下形成的核酸低聚物的液晶排序以及RNA和DNA的自组织组装的益生元意义。