In this work we reported, a simple and reproducible double‐step modified carbon paste electrode (CPE) for recognition and designation of Acyclovir (ACV). In the first stage, for acquiring the structure of TiO₂ NPs‐CPE, 5 % TiO₂ nanoparticles (NPs) doped into the electrode tissue. In the second stage, β‐Cyclodextrin (β‐CD) anchored on the TiO₂ NPs‐CPE surface by electropolymerization which yields a β‐CD/TiO₂ NPs‐CPE. Topography, characteristics and electrochemical response of the fabricated electrodes with such techniques as: the field emission scanning electron microscopy (FESEM), chronocoulometry (CC), cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were analyzed. Also the spent TiO₂ NPs powders were characterized by X‐ray diffraction (XRD). The results illustrated that this sensor designed efficiently increases the surface area of composite electrode and the performance of the oxidation of ACV at the surface modified electrode compared to the bare electrode improved. Under the desirable situations, the proposed of analytical procedure was proved to be applicable in two linear calibration ranges betwixt 0.09 to 2.98 and 2.98 to 47.61 μM. The detection limit was estimated for low concentrations ACV 21 nM (S/N=3). Eventually, the fabricated composite electrode was successfully applied for the detection of trace amounts of the ACV in the blood serum samples.

中文翻译：

---

使用TiO2纳米颗粒和β-环糊精制备用于阿昔洛韦痕量定量的双步修饰碳糊电极

在这项工作中，我们报告了一种用于识别和指定阿昔洛韦（ACV）的简单且可重现的双步修饰碳糊电极（CPE）。在第一阶段，为了获得TiO ₂ NPs-CPE的结构，将5％的TiO ₂纳米颗粒（NPs）掺杂到电极组织中。在第二阶段，通过电聚合将β-环糊精（β-CD）锚固在TiO ₂ NPs-CPE表面，产生β-CD/ TiO ₂ NPs-CPE。用场发射扫描电子显微镜（FESEM），计时库仑法（CC），循环伏安法（CV）和微分脉冲伏安法（DPV）等技术对所制备电极的形貌，特性和电化学响应进行了分析。也是用过的TiO ₂NPs粉末通过X射线衍射（XRD）表征。结果表明，与裸电极相比，该传感器的设计有效地增加了复合电极的表面积，并且在表面改性电极处的ACV氧化性能得到改善。在理想的情况下，该分析方法的建议被证明适用于0.09至2.98和2.98至47.61μM之间的两个线性校准范围。对于低浓度ACV 21 nM（S / N = 3）估计检测限。最终，所制造的复合电极成功地用于检测血清样品中的痕量ACV。