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Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study.
Neuropsychopharmacology ( IF 7.6 ) Pub Date : 2018-10-16 , DOI: 10.1038/s41386-018-0241-3
Daniel S Quintana 1 , Lars T Westlye 1, 2 , Dag Alnæs 1 , Tobias Kaufmann 1 , Ramy A Mahmoud 3 , Knut T Smerud 4 , Per G Djupesland 5 , Ole A Andreassen 1
Affiliation  

Little is known about how intranasally administered oxytocin reaches the brain and modulates social behavior and cognition. Pupil dilation is a sensitive index of attentional allocation and effort, and inter-individual variability in pupil diameter during performance of social-cognitive tasks may provide a better assessment of pharmacological effects on the brain than behavioral measures. Here, we leverage the close relationship between pupil and neural activity to inform our understanding of nose-to-brain oxytocin routes and possible dose-response relationships. To this end, we assessed pupil diameter data from a previously reported functional magnetic resonance imaging (fMRI) study under four treatment conditions-including two different doses of intranasal oxytocin using a novel Breath Powered nasal device, intravenous (IV) oxytocin, and placebo-and investigated the association with amygdala activation in response to emotional stimuli. The study used a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. A significant main effect of treatment condition on pupil diameter was observed. Posthoc tests revealed reduced pupil diameter after 8IU intranasal oxytocin compared to placebo, but no significant difference between 8IU intranasal oxytocin and either 24IU intranasal oxytocin or IV oxytocin treatment conditions. Analysis also showed a significant relationship between pupil diameter and right amygdala activation after 8IU intranasal oxytocin. Although there was no significant difference between 8IU intranasal oxytocin and IV oxytocin on right amygdala activity and pupil diameter, the significant difference between 8IU intranasal oxytocin and placebo is consistent with the hypothesis that oxytocin can travel to the brain via a nose-to-brain route.

中文翻译:

呼吸动力装置提供的低剂量鼻内催产素调节瞳孔直径和杏仁核活动:一项随机对照瞳孔测量和 fMRI 研究。

关于鼻内施用的催产素如何到达大脑并调节社会行为和认知,我们知之甚少。瞳孔扩张是注意力分配和努力的敏感指标,在执行社会认知任务期间瞳孔直径的个体间变异性可能比行为测量更好地评估药理对大脑的影响。在这里,我们利用瞳孔和神经活动之间的密切关系来了解我们对鼻到脑催产素途径和可能的剂量反应关系的理解。为此,我们评估了先前报道的功能磁共振成像 (fMRI) 研究在四种治疗条件下的瞳孔直径数据——包括使用新型呼吸动力鼻装置的两种不同剂量的鼻内催产素,静脉内 (IV) 催产素,和安慰剂 - 并研究了杏仁核激活对情绪刺激的反应。该研究采用随机、双盲、双模拟、交叉设计,16 名健康男性成年人单次服用这四种治疗方法。观察到治疗条件对瞳孔直径的显着主效应。事后测试显示,与安慰剂相比,8IU 鼻内催产素后瞳孔直径减小,但 8IU 鼻内催产素与 24IU 鼻内催产素或 IV 催产素治疗条件之间没有显着差异。分析还显示,8IU 鼻内催产素后瞳孔直径与右侧杏仁核激活之间存在显着关系。虽然 8IU 鼻内催产素和 IV 催产素对右侧杏仁核活动和瞳孔直径没有显着差异,
更新日期:2018-10-16
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