Significant progress in DNA nanotechnology has accelerated the development of molecular machines with functions like macroscale machines. However, the mobility of DNA self‐assembled nanorobots is still dramatically limited due to challenges with designing and controlling nanoscale systems with many degrees of freedom. Here, an origami‐inspired method to design transformable DNA nanomachines is presented. This approach integrates stiff panels formed by bundles of double‐stranded DNA connected with foldable creases formed by single‐stranded DNA. To demonstrate the method, a DNA version of the paper origami mechanism called a waterbomb base (WBB) consisting of six panels connected by six joints is constructed. This nanoscale WBB can follow four distinct motion paths to transform between five distinct configurations including a flat square, two triangles, a rectangle, and a fully compacted trapezoidal shape. To achieve this, the sequence specificity of DNA base‐pairing is leveraged for the selective actuation of joints and the ion‐sensitivity of base‐stacking interactions is employed for the flattening of joints. In addition, higher‐order assembly of DNA WBBs into reconfigurable arrays is achieved. This work establishes a foundation for origami‐inspired design for next generation synthetic molecular robots and reconfigurable nanomaterials enabling more complex and controllable motion.

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纸折纸启发的具有复杂运动的DNA纳米机的设计和启动

DNA纳米技术的显着进步促进了具有宏观功能等功能的分子机器的发展。然而，由于设计和控制具有许多自由度的纳米级系统的挑战，DNA自组装纳米机器人的移动性仍然受到极大限制。本文介绍了一种折纸启发的方法来设计可变形DNA纳米机器。这种方法整合了由双链DNA束与单链DNA形成的可折叠折痕连接而成的刚性面板。为了演示该方法，构建了一种纸折纸机制的DNA版本，称为水炸弹底座（WBB），该弹头由六个面板通过六个关节连接而成。这种纳米级WBB可以遵循四个不同的运动路径，以在五个不同的配置之间转换，包括平面正方形，两个三角形，一个矩形和完全压缩的梯形形状。为此，利用DNA碱基配对的序列特异性来选择性地激活关节，并利用碱基堆积相互作用的离子敏感性来使关节变平。此外，还可以将DNA WBB更高级别地组装成可重构阵列。这项工作为下一代合成分子机器人和可重构纳米材料提供了折纸启发的设计基础，从而实现了更复杂和可控制的运动。实现了将DNA WBB更高级别地组装成可重构阵列的功能。这项工作为下一代合成分子机器人和可重构纳米材料提供了折纸启发的设计基础，从而实现了更复杂和可控制的运动。实现了将DNA WBB更高级别地组装成可重构阵列的功能。这项工作为下一代合成分子机器人和可重构纳米材料提供了折纸启发的设计基础，从而实现了更复杂和可控制的运动。