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Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells
Small ( IF 13.3 ) Pub Date : 2018-10-11 , DOI: 10.1002/smll.201803342
Shuailong Zhang 1, 2, 3 , Nika Shakiba 1, 3 , Yujie Chen 4 , Yanfeng Zhang 4 , Pengfei Tian 5 , Jastaranpreet Singh 3 , M. Dean Chamberlain 1, 2, 3 , Monika Satkauskas 1, 2 , Andrew G. Flood 6 , Nazir P. Kherani 6, 7 , Siyuan Yu 4, 8 , Peter W. Zandstra 1, 3, 9, 10, 11 , Aaron R. Wheeler 1, 2, 3
Affiliation  

Optical micromanipulation has become popular for a wide range of applications. In this work, a new type of optical micromanipulation platform, patterned optoelectronic tweezers (p‐OET), is introduced. In p‐OET devices, the photoconductive layer (that is continuous in a conventional OET device) is patterned, forming regions in which the electrode layer is locally exposed. It is demonstrated that micropatterns in the photoconductive layer are useful for repelling unwanted particles/cells, and also for keeping selected particles/cells in place after turning off the light source, minimizing light‐induced heating. To clarify the physical mechanism behind these effects, systematic simulations are carried out, which indicate the existence of strong nonuniform electric fields at the boundary of micropatterns. The simulations are consistent with experimental observations, which are explored for a wide variety of geometries and conditions. It is proposed that the new technique may be useful for myriad applications in the rapidly growing area of optical micromanipulation.

中文翻译:

图案化光电镊子:选择,移动和存储介电粒子和电池的新方案

光学显微操作已在广泛的应用中流行。在这项工作中,介绍了一种新型的光学微操纵平台,即图案化的光电镊子(p-OET)。在p-OET器件中,对光电导层(在常规OET器件中是连续的)进行构图,从而形成电极层局部暴露的区域。事实证明,光电导层中的微图案可用于排斥不需要的颗粒/细胞,并且还可用于在关闭光源后将选定的颗粒/细胞保持在原位,从而最大程度地减少了光诱导的热量。为了弄清这些效应背后的物理机制,进行了系统仿真,这些仿真表明在微图案的边界处存在强的非均匀电场。该模拟与实验观察结果一致,已针对各种几何形状和条件进行了探索。提出了新技术对于在光学显微操作迅速发展的领域中的多种应用可能是有用的。
更新日期:2018-10-11
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