In article number 1802008, Da Xing, Xianglong Hu, and co‐workers propose a strategy of polyprodrug antimicrobials. The triclosan polyprodrug antimicrobials with diverse hydrophilic‐hydrophobic balance demonstrate remarkable membrane damage and concurrent triclosan release potency, which can efficiently inhibit methicillin‐resistant Staphylococcus aureus, a highly pathogenic bacteria associated with high mortality rates. Polyprodrug antimicrobials possess excellent antibacterial selectivity and undetectable antibiotic resistance when compared with commercial antibiotics.

中文翻译：

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Polyprodrug抗菌药物：Polyprodrug抗菌药物：明显的膜损伤和同时释放的药物可抵抗耐甲氧西林金黄色葡萄球菌的抗生素耐药性（Small 41/2018）

在第1802008号文章中，大兴，胡向龙和他的同事们提出了一种多药前药抗菌剂的策略。具有不同亲水-疏水平衡的三氯生多药前药显示出显着的膜损伤和同时释放三氯生的功效，可有效抑制耐甲氧西林的金黄色葡萄球菌（一种高致病性细菌，死亡率高）。与商业抗生素相比，多药前药具有出色的抗菌选择性和不可检测的抗生素抗性。