Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols†,Chemical Communications

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Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-10-11 00:00:00 , DOI: 10.1039/c8cc06388e
Heena Panchal _{1,

2,

3,

4,

5} , Christopher Clarke _{1,

2,

3,

4,

5} , Charles Bell _{1,

2,

3,

4,

5} , Somnath Narayan Karad _{1,

2,

3,

4,

5} , William Lewis _{2,

4,

5,

6,

7} , Hon Wai Lam _{1,

2,

3,

4,

5}

Affiliation

Nickel-catalyzed, highly diastereoselective annulations between activated allenes and 2-acetylarylboronic acid or 2-formylarylboronic acids are reported. No ligand for nickel is required, and the reactions proceed efficiently at room temperature to give a broad range of substituted 3-methyleneindan-1-ols. Preliminary results of an enantioselective variant are also described.

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