This study aimed to investigate the effects of 95% ethanol extract of G. frondosa (GF95) on lipid metabolism and gut microbiota composition in high-fat diet (HFD) fed rats. UPLC/Q-TOF MS indicated that GF95 was enriched with flavones, fatty acids and so on. Meanwhile, we found that body weight, serum lipid or liver index (total cholesterol, triglyceride, and low density lipoprotein cholesterol) levels were significantly decreased in GF95-treated HFD-fed rats. Furthermore, GF95 treatment regulated mRNA expression levels involved in lipid metabolism. GF95 consumption significantly enhanced the excretion of bile acids in the cecum. Besides, in this study, a higher abundance of Butyricimonas genus was revealed in the GF95 group, which is highly related to the highest production of short-chain fatty acids in the caecum contents among the experimental groups. Interestingly, results from network analysis showed that Butyricimonas were negatively correlated with serum and liver lipid profiles.

中文翻译：

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的效果灰树花95％乙醇提取物对脂质代谢和肠道菌群的组合物在高脂肪膳食喂养大鼠†

本研究的目的是调查的95％乙醇提取物的影响灰树花（GF95）对脂质代谢和肠道菌群的组合物在高脂肪膳食（HFD）喂养大鼠。UPLC / Q-TOF MS表明GF95富含黄酮，脂肪酸等。同时，我们发现在GF95治疗的HFD喂养的大鼠中，体重，血清脂质或肝指数（总胆固醇，甘油三酸酯和低密度脂蛋白胆固醇）水平显着降低。此外，GF95处理调节参与脂质代谢的mRNA表达水平。食用GF95显着增强了盲肠中胆汁酸的排泄。此外，在这项研究中，Butyricimonas的丰度更高属GF95组揭示了其属，这与实验组盲肠中短链脂肪酸的最高产生高度相关。有趣的是，网络分析结果表明，Butyricimonas与血清和肝脂质谱呈负相关。